Life-Threatening Reaction with Topical 5-Fluorouracil
نویسندگان
چکیده
منابع مشابه
Life-Threatening Reaction with Topical 5-Fluorouracil
A 67-year-old man developed a suspected adverse drug reaction during treatment with topical 5-fluorouracil (5-FU) for multiple actinic keratosis of the face, neck, and forearms. The man received topical 5-FU at a dosage of 0.5% for the actinic keratoses. After 1 week, he developed extreme lethargy, fatigue, fever, and mouth erosions. Several days later, and after discontinuation of 5-FU, painfu...
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In humans, 80-90% of an administered dose of 5-fluorouracil (5-FU) is degraded by dihydropyrimidine dehydrogenase (DPD; EC 1.3.1.2), the initial rate-limiting enzyme in pyrimidine catabolism. Cancer patients with decreased DPD activity are at increased risk for severe toxicity including diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity, and, in some cases, death. We now report th...
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Topical 5- Fluorouracil (5-FU) is used more frequently to treat actinic keratosis. We are presenting a skin reaction as a side effect of this medication. Treatment for such cases of 5-FU-induced skin reactions is based on proper skin care and treatment of any superimposed infections. Medical providers should be aware of such side effects to provide their patients with proper instructions to avo...
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Background: Epidermal nevus is a common skin hamartoma. Its definite treatment is difficult and in most cases the disease has recurrence. Objective: Evaluation of topical tretinoin 0.05% and 5 Fluorouracil (5FU) 5% in the treatment of epidermal nevus. Patients and Methods: Fifteen patients with epidermal nevus referred to skin clinic in Razi Hospital in Tehran whose diagnoses were confirm...
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Vitiligo is a common idiopathic acquired cutaneous pigmentary disorder resulting in depigmented skin. A wide variety of therapeutic modalities have been employed for its treatment, but none of them are satisfactory, in this study we have tested the effect of 5- fluorouracil 5FU on 54 patients with documented vitiligo in Kerman city. The following treatments were performed on three selected v...
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ژورنال
عنوان ژورنال: Drug Safety - Case Reports
سال: 2018
ISSN: 2199-1162,2198-977X
DOI: 10.1007/s40800-017-0068-6